Organoarsenic Compounds with In Vitro Activity against the Malaria Parasite Plasmodium falciparum
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چکیده
منابع مشابه
Protein tyrosine kinase activity in human malaria parasite Plasmodium falciparum.
Protein tyrosine kinases (PTKs) are believed to be implicated in the parasite growth, maturation and differentiation functions. Protein tyrosine kinase activity was found to be distributed in all the stages of P. falciparum parasite maturation. Membrane bound PTK activity was found to be increased during maturation process (ring stage to trophozoite stage) in chloroquine sensitive strains. In v...
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The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
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Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...
متن کاملPotent in vivo anti-malaria activity of Goniothalamin against rodent malaria parasite infection in mice
Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...
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The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the in...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2020
ISSN: 2227-9059
DOI: 10.3390/biomedicines8080260